METHODS OF DRUG DELIVERY, LACHRYMONASAL SYSTEM STRUCTURES AND COMPOSITIONS Russian patent published in 2011 - IPC A61F2/14 

FIELD: medicine.

SUBSTANCE: offered group of inventions aims at drug delivery and includes lachrymonasal system compositions and structures. Offered are a medicinal insert containing a coating and a medicated core. The medicinal insert is enclosed in an implant to be inserted into a patient's eye or adjacently. A medicated core comprises a therapeutically active substance contained in a matrix. Exposure of the active substance matrix to the lachrymal fluid provides effective prolonged release of the therapeutic active substance into the lachrymal fluid. In specific embodiments, the active substance matrix contains a non-bioabsorbable polymer, e.g. silicone, in an inhomogeneous mixture with the active substance. Also, there are offered a method for making the medicinal insert and implant configured for inserting into the patient's eye or adjacently, containing a passage adapted for receiving the medicinal insert or medicated core. Besides, the group of inventions involves the method of active substance delivery to the patient's eye, as well as the method of treating the patient's eye with using said implant containing the medicinal insert or medicated core.

EFFECT: enabled higher clinical effectiveness in the requiring patients due to target-specific prolonged drug delivery.

20 cl, 2 tbl, 10 dwg, 4 ex