FIELD: pharmaceutics.
SUBSTANCE: invention relates to a compound of the formula I, its pharmaceutically acceptable salt and its stereoisomer, which can be used to inhibit janus kinase JAK1. The invention also relates to a pharmaceutical composition for inhibiting the activity of janus kinase JAK1, including therapeutically effective amount of the specified compound, and to a method for the treatment of JAK1-mediated disease, including the injection of therapeutically effective amount of a compound of the formula I to a mammal.
EFFECT: aim of the invention is obtaining janus kinase inhibitors.
Formula I
18 cl, 1 dwg, 3 tbl, 1 ex
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