FIELD: pharmacology.
SUBSTANCE: group of inventions relates to the field of pharmacology, namely to photosensitisers based on chlorin e6. Photosensitiser for the treatment of cancer diseases contains chlorin e6 salt with N-methyl-D-glucamine (meglumine) and L-lysine in molar ratios of 1:2:1 and has the structural formula (I):
.
Also a method for the preparation of the photosensitiser for the treatment of cancer diseases is disclosed, which consists in adding to chlorin e6 salt the calculated amounts of N-methyl-D-glucamine (C7H17NO5) and L-lysine (C6H14N2O2) to the chlorin e6 salt, necessary to form the formula of salt (I), followed by filtration of the received solution of chlorin e6 double salt.
EFFECT: group of inventions provides the increased photo-induced activity of the photosensitiser during the photodynamic therapy of cancer diseases.
5 cl, 1 dwg, 5 ex, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| PHOTOSENSITISER AND METHOD OF ITS OBTAINING | 2013 |
|
RU2523380C1 |
| PHOTOSENSIBILIZATOR AND METHOD FOR ITS PREPARING | 2004 |
|
RU2276976C2 |
| METHOD FOR DETERMINING MAXIMUM CONCENTRATION TIME OF PHOTOSENSITIZER CHLORIN E6 LYSINE DIMEGLUMINE SALT IN TUMOR | 2019 |
|
RU2713941C2 |
| PHOTOSENSITISER AND METHOD FOR PREPARING THEREOF | 2008 |
|
RU2367434C1 |
| LIPOSOME-BASED PHOTOSENSITIZER WITH CURCUMIN FOR PHOTODYNAMIC THERAPY | 2023 |
|
RU2826499C1 |
| METHOD OF OBTAINING WATER-SOLUBLE METAL COMPLEX OF CHLORIN E6 WITH COPPER | 2022 |
|
RU2810784C1 |
| METHOD OF INTRAOPERATIVE PHOTODYNAMIC THERAPY IN COMBINED TREATMENT OF LOCALLY ADVANCED SOFT TISSUE SARCOMAS | 2020 |
|
RU2737704C2 |
| PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY OF PROSTATE CANCER AND METHOD FR MANUFACTURING THEREOF | 2018 |
|
RU2670087C1 |
| METHOD FOR PRODUCING COMPOSITION FOR PHOTODYNAMIC THERAPY IN FORM OF PHOSPHOLIPID NANOPARTICLES BASED ON GLUCAMINE CHLORINE E6 SALT, MALTOSE AND PHOSPHATIDYLCHOLINE | 2014 |
|
RU2576025C1 |
| PHOTOSENSITIZER BASED ON THE COMPLEX OF CHLORIN E6 AND EUROPIUM | 2022 |
|
RU2797948C1 |
