SUBSTANCE WITH ANTI-GLIOMA ACTIVITY AND METHOD OF PHOTODYNAMIC THERAPY OF GLIOBLASTOMA Russian patent published in 2023 - IPC A61K35/616 A61N5/67 A61P35/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: group of inventions relates to the use of an agent for photodynamic therapy (PDT) of neoplasms and a method for performing PDT using it. Application of the natural compound (3S,4S)-14-ethyl-9-(hydroxymethyl)-4,8,13,18-tetramethyl-20-oxo-3-forbinpropanoic acid, isolated from brittle stars of the family Ophiuroidea, such as brittle stars of the genus Ophiura, such as Ophiura sarsii, in as a photosensitizer with cytotoxic antiglioma activity. A method for carrying out photodynamic therapy, characterized by intravenous administration of photosensitizer (3S,4S)-14-ethyl-9-(hydroxymethyl)-4,8,13,18-tetramethyl-20-oxo-3-forbinpropanoic acid in an amount of 40 mg/kg of body weight, and then after 6 hours the pathological site is irradiated — the brain skull for 30 minutes with a laser light source with a power of 100 mW with a wavelength of 580 to 780 nm.

EFFECT: above agent has potent cytotoxic antiglioma activity and is suitable for use in photodynamic therapy.

2 cl, 1 tbl, 4 ex