MASS SPECTROMETRY METHOD OF IMPRINT ANALYSIS Russian patent published in 2011 - IPC A61B5/117 G01N33/483 

FIELD: medicine.

SUBSTANCE: invention refers to medicine. A matrix mass spectrometry technique is used to detect the presence of a residue in an imprint. A powder containing hydrophobic particles of silicon dioxide, as well as a metal, metal nitride, a metal oxide or carbon is applied on the imprint. An average particle diametre of said metal, metal nitride, metal oxide or carbon introduced in the hydrophobic particles of silicon dioxide is 65 to 90 mcm or 400 to 500 nm preferentially. The investigated imprint is lifted from the application area with using a lifting tape and brought in contact with a sample substrate of a mass spectrometre, then the powder is applied on the imprint. The powder is magnetic or paramagnetic and additionally contains a fluorescent or pigmented dye molecule. The mass spectrometry is conducted with using a matrix specified in a group including MALDI-TOF-MS-MS or SALDI-TOF-MS-MS and their combinations. The residue represents an endogenous residue, particularly endogenous and/or exogenous metabolites and a contact residue. The endogenous metabolite represents squalene, while the exogenous metabolite is nicotine metabolite, e.g. cotinine, and the contact residue is the drug cocaine.

EFFECT: method allows executing the imprint residue analysis on a human imprint directly that eliminates it to be replaced.

21 cl, 14 dwg