FIELD: chemistry.
SUBSTANCE: invention relates to a chemically modified molecule of a double stranded nucleic acid, which includes a sense chain and an antisense chain: 
, as well as a composition which contains such a molecule of the double strand nucleic acid.
EFFECT: nucleic acid molecule enables mediation of RNA-target activity through RNA interference and has high stability and activity in vivo.
5 cl, 43 dwg, 8 tbl, 16 ex
| Title |
Year |
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2011 |
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2018 |
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| TREATMENT OF CNS DISORDERS |
2007 |
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|
RU2426544C2 |
| TREATMENT OF ALPHA-L-IDURONIDASE (IDUA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IDUA |
2011 |
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| TREATMENT OF DISEASES ASSOCIATED WITH FRATAXIN (FXN), BY INHIBITING NATURAL ANTISENSE FXN TRANSCRIPT |
2012 |
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|
RU2620980C2 |
