FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to a method of increasing polynucleotide expression of alpha-L-Iduronidase (IDUA), and can be used in medicine. Invention also relates to identification of antisense oligonucleotides, which are targeted on natural antisense IDUA polynucleotide sequences chosen from SEQ ID NO: 2-9.
EFFECT: invention increases polynucleotide expression of IDUA, which can be used for treating diseases and disorders associated with IDUA gene expression.
39 cl, 5 dwg, 7 ex
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