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(19)

RU

(11)

2 419 611

(13)

C2

(51)

IPC

C07D223/12(2006-01-01)

C07D223/10(2006-01-01)

C07D401/12(2006-01-01)

C07D403/12(2006-01-01)

C07D409/14(2006-01-01)

C07D413/12(2006-01-01)

A61K31/55(2006-01-01)

A61P25/28(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2008103452/04, 2006-08-02

(24)

Start date

2006-08-02

(22)

Actual filing date

2006-08-02

(45)

Published

2011-05-27

(72)

Inventor

Flor AleksandrGallej GuidoJakob-Roehtne RolandKitas Ehrik ArgiriosVostl' Vol'Fgang

(73)

Holder

F. Khoffmann-Lja Rosh Ag

FLUORO-SUBSTITUTED 2-OXO-AZEPANE DERIVATIVES Russian patent published in 2011 - IPC C07D223/12 C07D223/10 C07D401/12 C07D403/12 C07D409/14 C07D413/12 A61K31/55 A61P25/28 A61P35/00 

Abstract RU 2419611 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of general formula

where there are R3/R3', R4/R4' and R5/R5' where at least one of either R4/R4' or R5/R5' always represents a fluorine atom, and the other radical values are disclosed in the description.

EFFECT: making the compounds which are γ-secretase inhibitors, and can be effective in treating Alzheimer's disease or advanced cancers, including but not limited to carcinoma of uterine cervix and breast carcinoma and malignant tumours of hematopoietic system.

15 cl, 3 tbl, 18 ex

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RU 2 419 611 C2

Authors

Flor Aleksandr

Gallej Guido

Jakob-Roehtne Roland

Kitas Ehrik Argirios

Vostl' Vol'Fgang

Dates

2011-05-27—Published

2006-08-02—Filed

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