PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS Russian patent published in 2011 - IPC C07D231/12 C07D401/10 C07D403/10 A61K31/415 A61K31/4178 A61K31/4439 A61K31/454 A61K31/496 A61K31/5377 A61P35/00 A61P43/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula which exhibits an inhibiting action on protein kinases A and B. In the compounds of formula (I), A represents a saturated hydrocarbon binding group containing 1 to 7 carbon atom where the binding group includes a chain of the maximum length 5 atoms located between R¹ and NR²R³, and a chain of the maximum length 4 atoms located between E and NR²R³ where one of carbon atoms in the binding group can be optionally substituted by an oxygen or nitrogen atom; and where the carbon atoms of the binding group A can optionally have one or more substitutes selected from oxo, fluorine and hydroxy provided the hydroxy group if any is not located on a carbon α-atom in relation to the NR²R³ group and provided the oxo group if any is located on the carbon α-atom in relation to the NR²R³; E represents a phenyl or pyridine group; R¹ represents a C_6-10aryl or pyridyl group which is not substituted or substituted with 1 or 2 substitutes specified in the patent claim; and R², R³, R⁴ and R⁵ have the values specified in the points of the patent claim.

EFFECT: invention refers to a pharmaceutical composition containing said compounds, to methods of making the compounds and their application as cancer drugs.

29 cl, 1 tbl, 108 ex