NOVEL 5,7-DISUBSTITUTED [1,3]THIAZOLO[4,5-d]PYRIMIDINE-2-(3H)-AMINE DERIVATIVES AND USE THEREOF IN THERAPY Russian patent published in 2011 - IPC C07D513/04 A61K31/519 A61P11/06 A61P9/10 A61P19/02 

Abstract RU 2437889 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general formula where R1 denotes CH3; R2 denotes halogen or CN; R3 denotes H or CH3; R4 denotes H or CH3; n equals 1; and pharmaceutically acceptable salts thereof. The invention also relates to a pharmaceutical composition and use of compounds of formula (I) in preparing a medicinal agent, having CX3CR1 receptor antagonist activity.

EFFECT: compounds can be used as CX3CR1 receptor antagonists.

13 cl, 1 tbl, 10 ex

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RU 2 437 889 C2

Authors

Jokhansson Rol'F

Karlstrem Sofija

Kers Annika

Nordvall' Gunnar

Rejn Tobias

Slivo Kan

Dates

2011-12-27Published

2007-09-27Filed