FIELD: chemistry.
SUBSTANCE: invention relates to production of magnetic composite materials, which can be used for targeted delivery of medicinal agents, as well as magnetic sorbents. In order to obtain a magnetic composite material based on iron oxides and molecular crystals, magnetic iron oxide is mixed with piroxicam or meloxicam. The weight ratio of piroxicam to iron oxide in the mixture is equal to 1:3, and the ratio of meloxicam to iron oxide in the mixture is equal to 1:3 or 1:10. Further, the mixture is mechanically treated in high-tension planetary-centrifugal or vibrating mills. When using a vibrating mill, the ratio of the weighing mass to the mass of the ball load is equal to 1:20 and acceleration equals 8-10 g. When using a planetary-centrifugal mill, the ratio of the weighing mass to the mass of the ball load equals 1:30 and the load on the ball is equal to 20 g.
EFFECT: invention reduces the rate of dissolution of piroxicam and meloxicam deposited on the surface of iron oxide.
3 dwg, 2 ex
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Authors
Dates
2011-06-20—Published
2009-11-09—Filed