FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to a product of oxymorphone hydrochloride exhibiting an analgesic activity and containing less than 10 parts/million of alpha, beta unsaturated ketones by HPLC, also the invention refers to a pharmaceutical formulation containing said product of oxymorphone hydrochloride and to a method of oxymorphone hydrochloride purification involving reduction of a basic substance of oxymorphone hydrochloride in highly acid aqueous and alcohol reaction medium with hydrogen gas at temperature within 60 to 70°C.
EFFECT: there is produced and described improved analgesic oxymorphone hydrochloride containing less than 10 parts/million of alpha, beta unsaturated ketones.
22 cl, 3 ex, 1 dwg
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