NOVEL CARBOSILANE DENDRIMERS, SYNTHESIS AND USE THEREOF Russian patent published in 2011 - IPC C08G77/50 C08G77/52 C07F7/18 A61K47/48 C12N15/87 

FIELD: chemistry.

SUBSTANCE: invention relates to carbosilane dendrimers and synthesis method and use thereof. Disclosed are novel dendrimers, the ends of branches of which include primary, secondary, tertiary and quaternary amino groups, synthesis method thereof, composition based on said dendrimers and versions of using said dendrimers. The disclosed dendrimers may be used to transport anionic molecules in blood, such as nucleic acid molecules, including ODN and RNAi molecules and other anionic medicinal agents with which they can interact, thus protecting them from interaction with proteins in the plasma and/or enhancing their degree of penetration into target cells. The dendrimers can be used to bind anionic molecules with surfaces, and can also be administered as active components for preventing or treating diseases caused by viruses such as HIV or hepatitis C, or prions whose life cycle can be disrupted by dendrimers.

EFFECT: obtaining novel carbosilane dendrimers, having a wide range of application in medicine and which are processable and biocompatible.

172 cl, 35 dwg, 19 tbl, 57 ex