RECOMBINANT PLASMID DNA CONTAINING SEQUENCE OF MATURE STAPHYLOKINASE Staphylococcus aureus WITH IDENTIFICATION PEPTIDE OF SIX HISTIDINE RESIDUES, Escherichia coli MZ08 STRAIN AND METHOD OF PRODUCING RECOMBINANT PROTEIN CONTAINING SEQUENCE OF MATURE STAPHYLOKINASE GENE WITH IDENTIFICATION PEPTIDE OF SIX HISTIDINE RESIDUES Russian patent published in 2011 - IPC C12N15/00 

Abstract RU 2422522 C2

FIELD: medicine.

SUBSTANCE: recombinant plasmid DNA coding protein of mature staphylokinase Staphylococcus aureus with identification peptide of six histidine residues is described. The Escherichia coli MZ08 strain - producer of recombinant protein of mature staphylokinase St. aureus with identification peptide of six histidine residues is offered. A method of producing recombinant protein of mature staphylokinase with identification peptide of six histidine residues is presented.

EFFECT: invention allows producing protein exhibiting high fibrinolytic activity, with reduced yield of recombinant protein of total.

3 cl, 2 dwg

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RU 2 422 522 C2

Authors

Vil'Kin Jakov Fimovich

Markin Sergej Sergeevich

Semenov Andrej Mikhajlovich

Dates

2011-06-27Published

2009-04-21Filed