FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to medicine. Benign nevus pigmentosis of skin can be treated by local application, in particular, external application, of composition of active ingredients of formula (I), where in formula (I) X is CO, CHOZ or CHNRZ, where Z is selected from hydrogen; unbranched or branched (C1-C6) alkyl; unbranched or branched (C2-C6) alkenyl; unbranched or branched (C2-C6) alkinyl, (C3-C8) cycloalkyl; (C6-C24) aryl; (C7-C24) aralkyl; m- and n-CH2(C6H4)COOM; COR3; CSR3; C(NR6)R3; SOR4; SO2OM; SO2NR7R8; SO2O-artemisinyl; SO2NH- artemisinyl; POR4R5 and PSR4R5; where R3 is unbranched or branched (C1-C6) alkyl; unbranched or branched (C2-C6) alkoxy; unbranched or branched (C2-C6) alkenyl; unbranched or branched (C2-C6) alkinyl; (C3-C8) cycloalkyl; (C6-C24) aryl; (C6-C10) aryloxy; (C7-C24) aralkyl; -(CH2)n-COOM, where n it is integer from 1 to 6; or 10α-di-hydro artemisinyl; R4 and R5 are selected independently on each other from unbranched or branched (C1-C6) alkyl; unbranched or branched (C2-C6) alkenyl; unbranched or branched (C2-C6) alkinyl; (C3-C8) cycloalkyl; (C6-C24) aryl; (C7-C24) aralkyl; OM; unbranched or branched (C1-C6) alkoxy; (C6-C10) aryloxy and NR7 R8; R6 are selected from unbranched or branched (C1-C6) alkyl; unbranched or branched (C2-C6) alkenyl; unbranched or branched (C2-C6) alkinyl; (C3-C8) cycloalkyl; (C6-C24) aryl and (C7-C24) aralkyl; M is hydrogen or pharmaceutically acceptable cation; and R7 and R8 are independently on each other hydrogen or unbranched or branched (C1-C6) alkyl, or R7 and R8 together form (C4-C6) alkylene bridge; and R is selected from hydrogen and groups, listed for R6 . These compounds are also effective in prevention of acquired nevuses from nevoid cells.
EFFECT: during treatment with formula (1) compounds healthy tissue is not damaged, and treatment is painless and simple.
26 cl, 1 tbl, 10 ex
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