FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to use of the compound of formula (1) and a pharmaceutical composition based thereon for treating or preventing seborrheic keratosis, where X is CO, CHOZ or CHNRZ; Z is selected from hydrogen; unbranched and branched (C1-C6) alkyl; unbranched or branched (C2-C6) alkenyl; unbranched or branched (C2-C6) alkynyl; (C3-C8) cycloalkyl; (C6-C24) aryl; (C7-C24) aralkyl; m- and p-CH2(C6H4)COSM; COR3; CSR3; C(NR6)R3; SOR4; SO2R3R3N; SO2OM; SO2NR7R8; SO2O-artemisinyl; SO2NH-artemisinyl; POR4R5; PSR4R5; and SO2R3; R3 is selected from unbranched or branched (C1-C6) alkyl; unbranched or branched (C1-C6) alkoxy; unbranched or branched (C2-C6) alkenyl; unbranched or branched (C2-C6) alkynyl; (C3-C8) cycloalkyl; (C6-C24) aryl; (C6-C10) aryloxy; (C7-C24) aralkyl; - (CH2)n-OCO, where n is integer from 1 to 6; and 10α-di-hydro-artemisilil; R4 and R5 are independently selected from unbranched or branched (C1-C6) alkyl; unbranched or branched (C2-C6) alkenyl; unbranched or branched (C2-C6) alkynyl; (C3-C8) cycloalkyl; (C6-C24) aryl; (C7-C24) aralkyl; OM; unbranched or branched (C1-C6) alkoxy; (C6-C10) aryloxy; and NR7R8; R6 is selected from unbranched or branched (C1-C6) alkyl; unbranched or branched (C2-C6) alkenyl; unbranched or branched (C2-C6) alkynyl; (C3-C8) cycloalkyl; (C6-C24) aryl; and (C7-C24) aralkyl; M is hydrogen or a pharmaceutically acceptable cation; R7 and R8 are independently selected from unbranched or branched (C1-C6) alkyl, or R7 and R8 together form (C4-C6) alkylene bridge; and R is selected from hydrogen; unbranched or branched (C1-C6) alkyl; unbranched or branched (C2-C6) alkenyl; unbranched or branched (C2-C6) alkynyl; (C3-C8) cycloalkyl; (C6-C24) aryl; and (C7-C24) aralkyl.
(1)
EFFECT: technical result is the new prescription of known compounds which can be used in medicine for treating or preventing seborrheic keratosis.
18 cl, 2 dwg, 1 tbl, 1 ex
