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2 423 992

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IPC

A61K36/29(2006-01-01)

A61K31/435(2006-01-01)

B01D11/02(2006-01-01)

(21) (22)

Application

2010106571/15, 2010-02-24

(24)

Start date

2010-02-24

(22)

Actual filing date

2010-02-24

(45)

Published

2011-07-20

(72)

Inventor

Nechepurenko Ivan Vasil'EvichPolovinka Marina PavlovnaKomarova Nina IvanovnaSalakhutdinov Nariman FaridovichTolstikov Genrikh Aleksandrovich

(73)

Holder

Novosibirskij Institut Organicheskoj Khimii Im. N.N. Vorozhtsova Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)

METHOD OF PREPARING PAKINSTAN AMINE AND BERBERINE CHLORIDE FROM BERBERIS SIBIRICA Russian patent published in 2011 - IPC A61K36/29 A61K31/435 B01D11/02

Abstract RU 2423992 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical and chemical industry, particularly to a method of preparing pakistan amine and berberine chloride. The method of preparing pakistan amine and berberine chloride by extraction of Siberian barberry (Berberis sibirica Pall.) roots with organic solvents (ethanol, methanol, acetone, and also their mixtures with water) followed by separation of a precipitate and pakistan amine sedimentation by a concentrated ammonia solution and pakistan amine purification by aluminium oxide column chromatography and further berberine chloride sedimentation from the remained filtrate by concentrated hydrochloric acid, with recrystalliszation purification of the settle down salt.

EFFECT: method allows higher yield of Siberian barberry alkaloids - pakistan amine and berberine chloride.

5 ex

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RU 2 423 992 C1

Authors

Nechepurenko Ivan Vasil'Evich

Polovinka Marina Pavlovna

Komarova Nina Ivanovna

Salakhutdinov Nariman Faridovich

Tolstikov Genrikh Aleksandrovich

Dates

2011-07-20—Published

2010-02-24—Filed