METHOD OF DETECTING SEVERITY OF DEGENERATIVE CHANGES IN BRAIN OF PATIENTS WITH DISSEMINATED SCLEROSIS Russian patent published in 2011 - IPC A61B6/03 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, diagnostics of severity of disseminated sclerosis. Analysis of images, obtained in course of magnetic-resonance tomography, weighed by T1 and T2 is carried out. T2 images of intracranial space are segmented using method of k-mean for liquor (L), white substance (WS) and gray substance (GS). In analysis of low-contrast images with low resolution, preliminarily on images, weighed by T2, intracranial space is segmented for L and brain parenchyma. Image of brain parenchyma is used as template, superimposed on images, weighed by T1, and by its means brain parenchyma is isolated, segmented for WS and GS and calculation of relative volumes (RV) of L and GS is performed by determination of ratio of their areas sum to sum of areas of intracranial space. Conclusion about severity of degenerative changes is made by increase of L RV and reduction of GS RV for more than statistical standard error from average values obtained from group of healthy people.

EFFECT: method ensures increase of accuracy of determination of degenerative change severity in brain due to their detection and estimation in grey substance of brain.

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