METHODS AND COMPOSITIONS WITH APPLICATION OF IMMUNOMODELLING COMPOUNDS IN COMBINED TREATMENT Russian patent published in 2011 - IPC A61K31/454 A61K31/19 A61K31/17 A61K31/165 A61P7/06 A61P35/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to medications and deals with composition for enhancing growth of hematopoetic stem cells CD34+, which contains efficient amount of immunomodelling compound, which represents 4-(amino)-2-(2,6-dioxo(3-pyperidyl))isoindoline-1,3-dione or 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)pyperidine-2,6-dione or its pharmaceutically acceptable salt and efficient amount of valproic acid or trichostatin A or their pharmaceutically acceptable salt. Invention also relates to method of enhancing growth of hematopoetic stem cells CD34+, method of treatment, prevention or controlling hematological disease or disorder, method of transplantation and recovery of bone marrow, method of treatment, prevention or controlling solid tumour, method of treatment, prevention or controlling leukoses and myelomas, method of treatment, prevention or controlling myelodysplastic syndrome and method of increasing expression of embryonic hemoglobin in cells.

EFFECT: compositions by the invention synergistically increase growth of hematopoetic stem cells CD34+.

23 cl, 16 dwg