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(19)

(11)

2 820 926

(13)

(51)

IPC

A01K67/27(2006-01-01)

C12N15/85(2006-01-01)

C12N5/10(2006-01-01)

(21) (22)

Application

2020127564, 2020-08-19

(24)

Start date

2009-06-29

(22)

Actual filing date

2020-08-19

(45)

Published

2024-06-13

(72)

Inventor

Houtzager, ErwinPinto, Rui DanielLogtenberg, TonThrosby, MarkKramer, Robert, ArjenDe Kruif, Cornelis, Adriaan

(73)

Holder

Merus B.V.

ANTIBODY-PRODUCING NON-HUMAN MAMMALS Russian patent published in 2024 - IPC A01K67/27 C12N15/85 C12N5/10

Abstract RU 2820926 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to a transgenic mammal containing a nucleic acid molecule integrated in its genome, coding a rearranged variable region of the light chain of human immunoglobulin and an animal light chain constant region, as well as to a method for production thereof. Also disclosed is a B-cell recovered from said transgenic mammal.

EFFECT: invention is effective for producing antibodies.

29 cl, 27 dwg, 11 tbl, 22 ex

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RU 2 820 926 C2

Authors

Houtzager, Erwin

Pinto, Rui Daniel

Logtenberg, Ton

Throsby, Mark

Kramer, Robert, Arjen

De Kruif, Cornelis, Adriaan

Dates

2024-06-13—Published

2020-08-19—Filed