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2 429 294

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(51)

IPC

C12N15/12(2006-01-01)

C12N15/79(2006-01-01)

C12N15/06(2006-01-01)

(21) (22)

Application

2009139151/10, 2009-10-23

(24)

Start date

2009-10-23

(22)

Actual filing date

2009-10-23

(45)

Published

2011-09-20

(72)

Inventor

Orlova Nadezhda AleksandrovnaKovnir Sergej VladimirovichVorob'Ev Ivan IvanovichJur'Ev Andrej SerafimovichMiroshnikov Anatolij IvanovichVorob'Ev Andrej Ivanovich

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Bioorganicheskoj Khimii Im. Akademikov M.M. Shemjakina I Ju.A. Ovchinnikova RanUchrezhdenie Rossijskoj Akademii Meditsinskikh Nauk Gematologicheskij Nauchnyj Tsentr Ramn

EXPRESSION GENETIC MAKER pOptivec/F8BDD CODING HUMAN RECOMBINANT BLOOD COAGULABILITY FACTOR VIII WITH DELETION OF B-DOMAIN AND CELL LINE DG-OV-F8BDD-18 PRODUCING HUMAN RECOMBINANT BLOOD COAGULABILITY FACTOR VIII WITH DELETION OF B-DOMAIN Russian patent published in 2011 - IPC C12N15/12 C12N15/79 C12N15/06

Abstract RU 2429294 C2

FIELD: medicine.

SUBSTANCE: expression plasmid DNA pOptivec/FSBDD coding the human recombinant blood coagulability factor VIII with deletion of B-domain which is used to transform cells of DG-OV-F8BDD-18 line for producing.

EFFECT: invention provides high secretion level of the human recombinant blood coagulability factor VIII with deletion of B-domain in a serum-free culture medium.

2 cl, 1 dwg, 2 ex

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RU 2 429 294 C2

Authors

Orlova Nadezhda Aleksandrovna

Kovnir Sergej Vladimirovich

Vorob'Ev Ivan Ivanovich

Jur'Ev Andrej Serafimovich

Miroshnikov Anatolij Ivanovich

Vorob'Ev Andrej Ivanovich

Dates

2011-09-20—Published

2009-10-23—Filed