METHOD OF IMMUNOCHEMICAL EVALUATION OF HUMAN LYMPHOCYTE PROLIFERATION BY MEANS OF NEW MARKER - NUCLEOLAR PROTEIN A3 Russian patent published in 2011 - IPC C12N15/07 G01N33/53 C07K1/13 

Abstract RU 2431670 C1

FIELD: medicine.

SUBSTANCE: method includes using a monoclonal A3 antibody for detection of a proliferation marker - nucleolar protein A3 followed by visualisation of positive focuses. A process of proliferation is shown by increasing focuses of A3 antigen localisation from one in G0 phase to 8-10 focuses in an S-period of a cell cycle.

EFFECT: invention allows evaluating effectively a condition of proliferative activity of human lymphocytes.

2 dwg, 1 ex

Similar patents RU2431670C1

Title Year Author Number
IMMUNOCYTOCHEMICAL METHOD FOR ASSESSING PHYTOHEMAGGLUTININ-STIMULATED LYMPHOCYTE BLAST-TRANSFORMATION REACTION (LBTR) 2012
  • Bulycheva Tat'Jana Ivanovna
  • Dejneko Natalija Leonidovna
  • Grigor'Ev Andrej Aleksandrovich
RU2514039C2
IMMUNOCYTOCHEMICAL ESTIMATION METHOD FOR PROLIFERATIVE LYMPHOCYTE STATE BY EXPRESSION BEHAVIOUR OF C-TERMINAL B23/NUCLEOPHOSMIN PROTEIN FRAGMENT IN INDIRECT IMMUNOFLUORESCENCE TEST 2010
  • Bulycheva Tat'Jana Ivanovna
  • Dejneko Natalija Leonidovna
RU2438135C1
METHOD FOR PROGNOSIS OF PROGRESSING CHRONIC LYMPHOLEUKOSIS BY QUANTITATIVE CONTENT OF NUCLEOLUS PROTEIN B23/NUCLEOFOZMINE IN LYMPHOID CELL LYSATES 2005
  • Bulycheva Tat'Jana Ivanovna
  • Dejneko Natal'Ja Leonidovna
  • Artemenko Elizaveta Georgievna
  • Samojlova Rimma Semenovna
  • Zatsepina Ol'Ga Vladimirovna
RU2310201C2
STRAIN OF CULTURED CELLS OF MURINE HYBRIDOMA A3 USED FOR OBTAINING MONOCLONAL ANTIBODIES AGAINST HUMAN CELL NUCLEOLUS ANTIGEN 2005
  • Bulycheva Tat'Jana Ivanovna
  • Kalinina Inna Aleksandrovna
  • Grigor'Ev Andrej Aleksandrovich
  • Zatsepina Ol'Ga Vladimirovna
RU2296159C2
STRAIN OF CULTURED MURINE HYBRIDOMA CELLS USED FOR PREPARING MONOCLONAL ANTIBODIES RAISED TO NUCLEOLUS ANTIGEN ASSOCIATED WITH CELLULAR PROLIFERATION 1998
  • Malashenko O.S.
  • Bulycheva T.I.
  • Dudnik O.A.
RU2145634C1
METHOD FOR PREOPERATIVE DIFFERENTIAL DIAGNOSIS OF BENIGN AND MALIGNANT NODULAR FORMATIONS OF THE THYROID GLAND 2021
  • Zima Dmitrij Vladimirovich
  • Bezrukov Oleg Filippovich
  • Zyablitskaya Evgeniya Yurevna
  • Golubinskaya Elena Petrovna
  • Makalish Tatyana Pavlovna
  • Maksimova Polina Evgenevna
  • Nepritimova Elena Andreevna
RU2783304C1
METHOD FOR MULTICOLORED IMMUNE-CYTOCHEMICAL DIAGNOSTICS OF PARANEOPLASIA OF CERVIX UTERI 2020
  • Zinovev Svyatoslav Vladimirovich
  • Moskvichev Maksim Andreevich
  • Utkin Oleg Vladimirovich
  • Kruglova Irina Aleksandrovna
  • Kuznetsova Sofya Alekseevna
  • Grachev Aleksej Nikolaevich
  • Kruglova Olga Vladimirovna
RU2753236C1
METHOD FOR PRODUCTION OF POLYCLONAL T-CELL VACCINE USEFUL IN TREATMENT OF IMMUNOLOGICAL DISORDERS 2004
  • Seledtsov Viktor Ivanovich
  • Ivanova Irina Petrovna
  • Samarin Denis Mikhajlovich
  • Kozlov Vladimir Aleksandrovich
RU2277422C2
METHOD FOR EVALUATING LYMPHOCYTE BLAST-TRANSFORMATION REACTION BY FLOW CYTOMETRY AT SPECIFIC ACTIVATION BY ANTIGEN 2015
  • Ponomarenko Dmitrij Grigorevich
  • Sarkisjan Nushik Saakovna
  • Kostjuchenko Marina Vladimirovna
  • Logvinenko Olga Vasilevna
  • Rakitina Ekaterina Lvovna
  • Kulichenko Aleksandr Nikolaevich
RU2582395C1
METHOD OF DETECTING PROTEINS IN DIFFERENT CELL TYPES OF MAMMALS AND HUMAN USING FLUORESCEIN-5-ISOTHIOCYANATE AT MICROSCOPIC LEVEL 2013
  • Shishova Ksenija Viktorovna
  • Lavrent'Eva Elena Andreevna
  • Zatsepina Ol'Ga Vladimirovna
RU2547594C2

RU 2 431 670 C1

Authors

Bulycheva Tat'Jana Ivanovna

Grigor'Ev Andrej Aleksandrovich

Dejneko Natalija Leonidovna

Dates

2011-10-20Published

2010-04-01Filed