BENZOTRIAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY Russian patent published in 2019 - IPC C07D249/18 C07D403/14 C07D413/14 A61K31/4192 A61K31/506 A61K31/5377

Abstract RU 2677696 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (IIB) or a pharmaceutically acceptable salt thereof. In formula (IIB), E is -CH₂-; V is N; R¹² is hydrogen; R¹⁵ denotes a difluoromethoxy group; R¹⁶ is hydrogen; R²¹ means piperidinyl, piperazinyl or morpholinyl, any of these groups may optionally contain 1, 2 or 3 substituents independently selected from C₁-C₆-alkylsulfonyl, oxo groups and carboxy groups; and R²³ is hydrogen. Also the invention relates to a pharmaceutical composition, to the use of a compound, to a method for treating and/or preventing rheumatoid arthritis or Crohn's disease.

(IIB).

EFFECT: obtained new compounds of formula (IIB) with the properties of the modulator of TNFα activity.

6 cl, 6 ex

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RU 2 677 696 C1

Authors

Brukings Daniel Kristofer

Kroplin Boris

Dates

2019-01-21—Published

2014-12-08—Filed