VERSION FORM URATE-OXYDASE AND ITS USE Russian patent published in 2011 - IPC C12N9/02 C12N15/53 C12N15/11 C12P21/00 

FIELD: medicine.

SUBSTANCE: there are presented version forms of uricase containing sequences referred in the description. Also, there is presented a recovered nucleic acid containing a nucleotide sequence which codes said uricase, and said nucleic acid is operatively bound with a heterological promoter. There is described an expression vector containing said nucleic acid and a host cell containing this vector and being an uricase producer. There are described a method for producing uricase involving stages of cultivation of said host cells under conditions when the nucleic acid sequence is expressed by the host cells, and of uricase recovery.

EFFECT: invention allows relieving hyperuricemia and hyperuricosuria.

13 cl, 8 dwg, 7 tbl, 8 ex