FIELD: biochemistry.
SUBSTANCE: present invention relates to biochemistry, in particular to a conjugate of urate oxidase (uricase), intended for decreasing uric acid levels a subject. Said conjugate comprises isolated shortened mammal uricase, having amino acid sequence SEQ ID NO:11, which is shortened from amine end by 6 amino acids and additionally contains amino acid replacements S46T, D7T, R291K and T301S, and polyethylene glycol. Present invention discloses a pharmaceutical composition for reducing uric acid levels in a subject, as well as a method of decreasing uric acid levels in a subject using said conjugate of uricase and polyethylene glycol.
EFFECT: present invention widens the range of products for controlling excess concentration of uric acid (hyperuricemia) in an individual when treating such diseases as gout, gout nodule, renal failure and others.
45 cl, 8 dwg, 7 tbl, 8 ex
| Title |
Year |
Author |
Number |
| ALTERNATIVE FORMS OF URATE OXIDASE AND USING THEM |
2006 |
- Khartman Jakob
- Mendelovits Simona
|
RU2451074C2 |
| VERSION FORM URATE-OXYDASE AND ITS USE |
2006 |
- Khartman Jakob
- Mendelovitts Simona
|
RU2435847C2 |
| URATE OXIDASE CONJUGATES, PHARMACEUTICAL COMPOSITION FOR REDUCTION IN URIC ACID LEVELS AND METHOD FOR PREPARING CONJUGATES STATED ABOVE |
2008 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermen Meri R.
|
RU2443426C2 |
| URICASE PEG-CONJUGATES AND THEIR APPLYING |
1999 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Merri R.
|
RU2246318C2 |
| PEG-URATE OXIDASE CONJUGATES, THEIR APPLICATION, METHOD OF TETRAMERIC URICASE FORM SEPARATION |
2006 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Mehrri R.
|
RU2349341C2 |
| METHOD FOR ISOLATION OF TETRA-DIMENSIONAL FORM OF URICASE AND URICASE |
1999 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Mehrri R.
|
RU2278680C2 |
| URATE OXIDASE FREE FROM UNITS FOR PREPARATION OF NONIMMUNOGENIC POLYMERIC CONJUGATES |
2001 |
- Sherman Mehrri R.
- Sehjfer Mark Dzh. P.
- Vil'Jams L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzan Dzh.
|
RU2352354C2 |
| PURIFIED PREPARATION OF URATE OXIDASE, PURIFIED RECOMBINANT URATE OXIDASE, CONJUGATE (VERSIONS) AND PHARMACEUTICAL COMPOSITION FOR REDUCING MAMMALIAN LIQUID OR TISSUE URIC ACID, PURIFIED FRAGMENTS OF URATE OXIDASE AND METHOD FOR URATE OXIDASE PURIFICATION |
2009 |
- Villiamz, L., Dehvid
- Kelli, S'Juzehn, Dzh.
- Sajfer, Mark, Dzh., P.
- Khershfild, Majkl, S.
- Shermen, Meri, R.
|
RU2557318C9 |
| RECOMBINANT MAMMALIAN URICASE PROTEIN FOR CONJUNCTION WITH PEG, NUCLEIC ACID MOLECULE ENCODING THE SAME EXPRESSION VECTOR, METHODS FOR PRODUCTION ABD USES THEREOF |
1999 |
- Khershfild Majkl
- Kelli S'Juzn Dzh.
|
RU2290439C2 |
| PURIFIED PREPARATION OF MAMMALIAN URICASE, METHOD FOR ITS PREPARING, PREPARATION OF ACTIVE URICASE CONJUGATE AND PHARMACEUTICAL COMPOSITION |
2001 |
- Sherman Merri R.
- Sehjfer Mark Dzh. P.
- Vil'Jams L. Dehvid
|
RU2281954C2 |
