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(19)

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2 557 318

(13)

(51)

IPC

C12N9/02(2006-01-01)

C12N15/53(2006-01-01)

C12N15/11(2006-01-01)

(21) (22)

Application

2009104003/10, 2009-02-06

(24)

Start date

2001-02-07

(22)

Actual filing date

2009-02-06

(45)

Published

2015-07-20

(72)

Inventor

Villiamz, L., DehvidKelli, S'Juzehn, Dzh.Sajfer, Mark, Dzh., P.Khershfild, Majkl, S.Shermen, Meri, R.

(73)

Holder

Muntehn V'Ju Farmas'Jutikehlz, Ink.Djuk Juniversiti

PURIFIED PREPARATION OF URATE OXIDASE, PURIFIED RECOMBINANT URATE OXIDASE, CONJUGATE (VERSIONS) AND PHARMACEUTICAL COMPOSITION FOR REDUCING MAMMALIAN LIQUID OR TISSUE URIC ACID, PURIFIED FRAGMENTS OF URATE OXIDASE AND METHOD FOR URATE OXIDASE PURIFICATION Russian patent published in 2015 - IPC C12N9/02 C12N15/53 C12N15/11

Abstract RU 2557318 C9

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to biotechnology and represents a purified recombinant urate oxidase (uricase) characterised by the tetramer and octamer content of 95% and more of the total molecule count. The invention also discloses a purified preparation of the above urate oxidase possessing lower immunogenicity, a conjugate of the above urate oxidase and polyethylene glycol or polyethylene oxide used to reduce mammalian tissue or liquid uric acid, purified fragments of the above urate oxidase, a pharmaceutical composition containing the above urate oxidase and a method for purifying the above urate oxidase with maintaining its uricolytic activity, involving the separation and removal of uricase aggregates bigger than octamers.

EFFECT: present invention enables producing the preparations of urate oxidase of lower immunogenicity.

23 cl, 6 dwg, 6 ex

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RU 2 557 318 C9

Authors

Villiamz, L., Dehvid

Kelli, S'Juzehn, Dzh.

Sajfer, Mark, Dzh., P.

Khershfild, Majkl, S.

Shermen, Meri, R.

Dates

2015-07-20—Published

2009-02-06—Filed