FIELD: medicine.
SUBSTANCE: what is offered is an active recombinant protein of uricase which represents a mutant form of mammal uricase truncated in the N-terminal by 6 amino acid residues which contains substitutes S46T, D7T, R291K and T301S.
EFFECT: truncated uricase under the invention is characterised by a lower immunogenicity level and higher structural stability.
| Title |
Year |
Author |
Number |
| VARIANT FORMS OF URATE OXIDASE AND USE THEREOF |
2012 |
- Khartman Yakob
- Mendelovits Simona
|
RU2610680C9 |
| VERSION FORM URATE-OXYDASE AND ITS USE |
2006 |
- Khartman Jakob
- Mendelovitts Simona
|
RU2435847C2 |
| URATE OXIDASE CONJUGATES, PHARMACEUTICAL COMPOSITION FOR REDUCTION IN URIC ACID LEVELS AND METHOD FOR PREPARING CONJUGATES STATED ABOVE |
2008 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermen Meri R.
|
RU2443426C2 |
| URICASE PEG-CONJUGATES AND THEIR APPLYING |
1999 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Merri R.
|
RU2246318C2 |
| METHOD FOR ISOLATION OF TETRA-DIMENSIONAL FORM OF URICASE AND URICASE |
1999 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Mehrri R.
|
RU2278680C2 |
| PEG-URATE OXIDASE CONJUGATES, THEIR APPLICATION, METHOD OF TETRAMERIC URICASE FORM SEPARATION |
2006 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Mehrri R.
|
RU2349341C2 |
| RECOMBINANT MAMMALIAN URICASE PROTEIN FOR CONJUNCTION WITH PEG, NUCLEIC ACID MOLECULE ENCODING THE SAME EXPRESSION VECTOR, METHODS FOR PRODUCTION ABD USES THEREOF |
1999 |
- Khershfild Majkl
- Kelli S'Juzn Dzh.
|
RU2290439C2 |
| URATE OXIDASE FREE FROM UNITS FOR PREPARATION OF NONIMMUNOGENIC POLYMERIC CONJUGATES |
2001 |
- Sherman Mehrri R.
- Sehjfer Mark Dzh. P.
- Vil'Jams L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzan Dzh.
|
RU2352354C2 |
| PURIFIED PREPARATION OF URATE OXIDASE, PURIFIED RECOMBINANT URATE OXIDASE, CONJUGATE (VERSIONS) AND PHARMACEUTICAL COMPOSITION FOR REDUCING MAMMALIAN LIQUID OR TISSUE URIC ACID, PURIFIED FRAGMENTS OF URATE OXIDASE AND METHOD FOR URATE OXIDASE PURIFICATION |
2009 |
- Villiamz, L., Dehvid
- Kelli, S'Juzehn, Dzh.
- Sajfer, Mark, Dzh., P.
- Khershfild, Majkl, S.
- Shermen, Meri, R.
|
RU2557318C9 |
| PURIFIED PREPARATION OF MAMMALIAN URICASE, METHOD FOR ITS PREPARING, PREPARATION OF ACTIVE URICASE CONJUGATE AND PHARMACEUTICAL COMPOSITION |
2001 |
- Sherman Merri R.
- Sehjfer Mark Dzh. P.
- Vil'Jams L. Dehvid
|
RU2281954C2 |
