FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmacology and medicine and represents urate oxidase (uricase) conjugates for reduction in high uric acid levels in fluids and tissues of a mammal body, containing purified uricase and polyethylene glycol (PEG) in which at least 90% of said uricase represents a tetramer, and each subunit of said uricase is covalently bound with in average at most 12 polyethylene glycol filaments having a molecular weight approximately from 5 kDa to approximately 100 kDa.
EFFECT: invention provides elimination of urate oxidase immunogenicity with no impairment of uric acid decomposition activity.
31 cl, 12 ex, 1 tbl, 17 dwg
| Title |
Year |
Author |
Number |
| URATE OXIDASE FREE FROM UNITS FOR PREPARATION OF NONIMMUNOGENIC POLYMERIC CONJUGATES |
2001 |
- Sherman Mehrri R.
- Sehjfer Mark Dzh. P.
- Vil'Jams L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzan Dzh.
|
RU2352354C2 |
| URICASE PEG-CONJUGATES AND THEIR APPLYING |
1999 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Merri R.
|
RU2246318C2 |
| PEG-URATE OXIDASE CONJUGATES, THEIR APPLICATION, METHOD OF TETRAMERIC URICASE FORM SEPARATION |
2006 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Mehrri R.
|
RU2349341C2 |
| METHOD FOR ISOLATION OF TETRA-DIMENSIONAL FORM OF URICASE AND URICASE |
1999 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Mehrri R.
|
RU2278680C2 |
| PURIFIED PREPARATION OF URATE OXIDASE, PURIFIED RECOMBINANT URATE OXIDASE, CONJUGATE (VERSIONS) AND PHARMACEUTICAL COMPOSITION FOR REDUCING MAMMALIAN LIQUID OR TISSUE URIC ACID, PURIFIED FRAGMENTS OF URATE OXIDASE AND METHOD FOR URATE OXIDASE PURIFICATION |
2009 |
- Villiamz, L., Dehvid
- Kelli, S'Juzehn, Dzh.
- Sajfer, Mark, Dzh., P.
- Khershfild, Majkl, S.
- Shermen, Meri, R.
|
RU2557318C9 |
| PURIFIED PREPARATION OF MAMMALIAN URICASE, METHOD FOR ITS PREPARING, PREPARATION OF ACTIVE URICASE CONJUGATE AND PHARMACEUTICAL COMPOSITION |
2001 |
- Sherman Merri R.
- Sehjfer Mark Dzh. P.
- Vil'Jams L. Dehvid
|
RU2281954C2 |
| RECOMBINANT MAMMALIAN URICASE PROTEIN FOR CONJUNCTION WITH PEG, NUCLEIC ACID MOLECULE ENCODING THE SAME EXPRESSION VECTOR, METHODS FOR PRODUCTION ABD USES THEREOF |
1999 |
- Khershfild Majkl
- Kelli S'Juzn Dzh.
|
RU2290439C2 |
| VARIANT FORMS OF URATE OXIDASE AND USE THEREOF |
2012 |
- Khartman Yakob
- Mendelovits Simona
|
RU2610680C9 |
| ALTERNATIVE FORMS OF URATE OXIDASE AND USING THEM |
2006 |
- Khartman Jakob
- Mendelovits Simona
|
RU2451074C2 |
| VERSION FORM URATE-OXYDASE AND ITS USE |
2006 |
- Khartman Jakob
- Mendelovitts Simona
|
RU2435847C2 |
