FIELD: medicine.
SUBSTANCE: group of inventions refers to veterinary science, and concerns inactivated chimeric vaccines and related methods of application. Substance of the inventions involves an inactivated chimeric flavivirus containing a first flavivirus representing a yellow fever virus in which nucleotide sequences coding pre-membrane and membrane proteins are substituted by nucleotide sequences coding pre-membrane and membrane proteins a second flavivirus representing a West Nile fever virus. The inventions also involve an immunogenic composition and a vaccine for protection of animals from the flavivirus infections, involving the inactivated chimeric flavivirus.
EFFECT: development of the advanced immunogenic composition and the vaccine on the basis of the inactivated chimeric flavivirus.
14 cl, 3 ex, 5 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| VACCINE AGAINST VIRUS OF WEST NILE ENCEPHALITIS | 2003 |
|
RU2376374C2 |
| METHODS FOR PROPHYLAXIS AND TREATMENT FLAVIVIRUS INFECTIONS IN ANIMAL | 2002 |
|
RU2313367C2 |
| CHIMERIC FLAVIVIRAL VACCINES | 1998 |
|
RU2209082C2 |
| RECOMBINANT FLAVIVIRAL VACCINES | 2006 |
|
RU2465326C2 |
| CHIMERIC VACCINES BASED ON VIRUSES OF FLAVIVIRUS AND LYSSAVIRUS GENES | 2019 |
|
RU2816136C2 |
| FLAVIVIRUS WITH BIPARTITE GENOME AND USING IT | 2008 |
|
RU2527891C2 |
| LYOPHILISED COMPOSITION FOR INDUCING IMMUNE RESPONSE TO FLAVIVIRUS, COMPOSITION AND METHOD FOR PREPARING IT | 2007 |
|
RU2541784C2 |
| IMMUNOBIOLOGICAL AGENT FOR THE PREVENTION OF DISEASES CAUSED BY TICK-BORNE ENCEPHALITIS VIRUS BASED ON A RECOMBINANT VIRUS OF THE GENUS FLAVIVIRUS | 2022 |
|
RU2795800C1 |
| DNA-CONSTRUCT OF VIABLE CHIMERIC RECOMBINANT FLAVIVIRUS AGAINST TICK-BORNE ENCEPHALITIS VIRUS, METHOD OF PROPHYLAXIS OF INFECTION MAMMAL WITH TICK-BORNE ENCEPHALITIS VIRUS | 1998 |
|
RU2208635C2 |
| RECOMBINANT PLASMID VECTOR pET32-WNV-DIII, PROVIDING SYNTHESIS AND SECRETION OF RECOMBINANT DOMAIN III OF STRUCTURAL GLYCOPROTEIN E OF WEST NILE VIRUS IN ESCHERICHIA COLI CELLS, ESCHERICHIA COLI BL21(DE3)-DIII-WNV CELL LINE STRAIN AND DIII-WNV RECOMBINANT PROTEIN FOR PREPARING IMMUNOBIOLOGICAL PREPARATIONS | 2024 |
|
RU2821341C1 |
