FLAVIVIRUS WITH BIPARTITE GENOME AND USING IT Russian patent published in 2014 - IPC C12N7/01 C12N5/10 A61K39/12 A61P31/14 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to biotechnology, virology and medicine. The first flaviviral particle comprises a psudoinfecting viral genome coding cis-active promoter elements required for the RNA replication, coat proteins and a complete kit of non-structural proteins of the flavivrus, and not coding capside proteins of the flavivirus. The second flaviviral particle comprises a complementary genome coding the cis-active promoter elements required for the RNA replication, a capside protein and a complete kit of proteins of the flavivrus, and not coding coat proteins. Since the genetic material of the flavivirus is distributed between two genomes, the flavivirus is replication-deficient and is not able to induce a disease, however it is able to induce an immune response. What is also described is a method for preparing this combination, a pharmaceutical composition and a method for using it. The invention can be used in medicine.

EFFECT: what is presented is a combination of the flaviviral particles.

13 cl, 18 dwg, 14 ex