FIELD: medicine.
SUBSTANCE: invention relates to medicine, photodynamic therapy of tumours. Photosensitiser (PS), in particular radachlorine is added to nanoparticles of emulsion of perfluorocarbons (PFC), consisting of perfluorodecalin and perfluoromethylcyclohexylpiperidine, stabilised with proxanol 268 solution. Emulsion of PFC with PS is added to stem cells of bone marrow (SCBM), in particular, autologic. Their joined cultivation is carried out, after which SCBM is introduced to subject with malignant tumour, in particular breast tumour. Zone of tumour growth is subjected to impact by light irradiation in dose sufficient for complete or partial tumour destruction. Subject can be represented by a mammal, in particular, human being.
EFFECT: method ensures targeted impact, complete or partial tumour regress, excludes systemic phototoxic injuries.
6 cl, 3 ex, 3 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PHOTODYNAMIC THERAPY | 2015 |
|
RU2637279C2 |
| METHOD OF TARGETED TRANSPORT OF BIOLOGICALLY ACTIVE SUBSTANCES AND APPLICATION OF STEM CELLS FOR TARGETED TRANSPORT | 2009 |
|
RU2426785C1 |
| COMPOSITION FOR APPLICATION IN PHOTODYNAMIC THERAPY OF CANCER | 2016 |
|
RU2626600C1 |
| METHOD OF INCREASING EFFECIENCY OF PHOTODYNAMIC THERAPY OF CHOROIDAL NEOVASCULARISATION | 2008 |
|
RU2375023C1 |
| METHOD OF ELECTROCHEMICAL DESTRUCTION AND PHOTODYNAMIC THERAPY FOR CHOROID MELANOMA | 2007 |
|
RU2336059C1 |
| METHOD OF ELECTROCHEMICAL LYSIS AND PHOTODYNAMIC THERAPY OF CHOROIDAL MELANOMA | 2011 |
|
RU2463026C1 |
| METHOD OF ELECTROCHEMICAL LYSIS AND PHOTODYNAMIC THERAPY OF CHOROIDAL MELANOMA | 2011 |
|
RU2463027C1 |
| METHOD OF TREATING BREAST CANCER | 2010 |
|
RU2435596C1 |
| METHOD OF INTRAOPERATIVE PHOTODYNAMIC THERAPY IN COMBINED TREATMENT OF LOCALLY ADVANCED SOFT TISSUE SARCOMAS | 2020 |
|
RU2737704C2 |
| METHOD FOR APPLYING PHOTODYNAMIC CHOROIDEA MELANOMA THERAPY | 2006 |
|
RU2318511C1 |
