FIELD: medicine.
SUBSTANCE: microparticles are made from a copolymer of lactic and glycolic acids containing a photosensitizer. The obtained microparticles are added to the stem cells and their co-cultivation is carried out. After this, the stem cells are introduced to the subject with the tumour, and the tumour growth zone is exposed to light irradiation at a dose sufficient to completely or partially destroy the tumour.
EFFECT: targeting effect with increased amount of the photosensitizer being transported, reducing the toxic effect of the latter on stem cells and eliminating systemic phototoxic damage.
10 cl, 1 tbl, 8 ex, 2 dwg
Title | Year | Author | Number |
---|---|---|---|
METHOD OF PHOTODYNAMIC THERAPY OF SUBJECTS WITH MALIGNANT TUMOURS | 2010 |
|
RU2440158C2 |
METHOD OF TARGETED TRANSPORT OF BIOLOGICALLY ACTIVE SUBSTANCES AND APPLICATION OF STEM CELLS FOR TARGETED TRANSPORT | 2009 |
|
RU2426785C1 |
METHOD OF TREATING SOLID MALIGNANT GROWTHS AND THEIR METASTASES | 2010 |
|
RU2437692C2 |
COMPOSITION FOR APPLICATION IN PHOTODYNAMIC THERAPY OF CANCER | 2016 |
|
RU2626600C1 |
METHOD OF INTRAOPERATIVE PHOTODYNAMIC THERAPY IN COMBINED TREATMENT OF LOCALLY ADVANCED SOFT TISSUE SARCOMAS | 2020 |
|
RU2737704C2 |
PHARMACEUTICAL COMPOSITION FOR PHOTODYNAMIC TREATMENT AND METHOD OF TREATMENT OF ONCOLOGY DISEASES WITH USE OF COMPOSITION | 2005 |
|
RU2323722C2 |
MONOCATIONIC CHLORINE PHOTOSENSITIZER FOR PHOTODYNAMIC INACTIVATION OF TUMOR CELLS | 2022 |
|
RU2792003C1 |
PHOTOSENSITISER OF BACTERIOCHLORINE ROW FOR PHOTODYNAMIC THERAPY AND METHOD FOR ITS PREPARATION | 2019 |
|
RU2720806C2 |
MEANS FOR PHOTODYNAMIC THERAPY | 2016 |
|
RU2646834C1 |
METHOD FOR PHOTODYNAMIC THERAPY OF LEFT TUMORS OF MICE EHRLICH CARCINOMA WITH CHLORINE SERIES PHOTO-SENSITIZER | 2022 |
|
RU2788766C2 |
Authors
Dates
2017-12-01—Published
2015-12-25—Filed