FIELD: medicine, pharmaceutics.
SUBSTANCE: there are described compounds of formula
as well as their pharmaceutically acceptable salts where the substitutes are those as described in the patent claim. The compounds of formula (I) are 11β-hydroxysteroid dehydrogenase (11β-HSD) enzyme inhibitors.
EFFECT: making the compounds effective for treating and preventing the diseases, such as insulin-independent diabetes and metabolic syndrome, particularly obesity, eating disorders or dislipidemia.
15 cl, 1 tbl, 28 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PYRAZOLES | 2006 |
|
RU2381217C2 |
| IMIDAZOLYLDINONE DERIVATIVES AS B 11b-HSD1 INHIBITORS | 2009 |
|
RU2538986C2 |
| PYRAZOLES AS 11-BETA-HSD-1 INHIBITORS | 2007 |
|
RU2402517C2 |
| TRICYCLIC LACTAM DERIVATIVES AS 11-β-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | 2005 |
|
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| TETRAHYDROCINNOLINE DERIVATIVES | 2009 |
|
RU2541533C2 |
| ALKYL-PYRIDAZINE DERIVATIVES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1(11β-HSD 1) | 2007 |
|
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| PYRIMIDINE DERIVATIVES WITH INHIBITING ACTION WITH RESPECT TO 11b-HSD1 | 2005 |
|
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| ACIDIFIED INDANYLAMINES AND THEIR USE AS PHARMACEUTICAL PREPARATIONS | 2002 |
|
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| BENZOTHIAZINE DERIVATIVES, PRODUCTION AND USE THEREOF AS MEDICAL DRUGS | 2010 |
|
RU2523791C2 |
| PYRROLE DERIVATIVES AS MEDICINAL SUBSTANCES | 2005 |
|
RU2470916C2 |
