TETRAHYDROCINNOLINE DERIVATIVES Russian patent published in 2015 - IPC C07D237/28 C07D403/04 A61K31/502 A61P3/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula , wherein A represents CR^aR^b or -CH₂-CH₂-; R¹ represents hydrogen or alkyl; R² represents hydrogen or alkyl; R³ represents alkyl, cycloalkyl, cycloalkylalkyl, aryl, substituted aryl, 1H-pyrazolyl or substituted 1H-pyrazolyl, wherein substituted aryl represents aryl substituted by 1-3 substitutes independently specified in alkyl, halogen and halogenalkyl, and wherein substituted 1H-pyrazolyl represents 1H-pyrazolyl substituted by 1-3 substitutes independently specified in alkyl and aryl; R^a represents hydrogen or methyl; R^b represents hydrogen or methyl; or R^a and R^b together with a carbon atom, to which they are attached, form cyclopropyl, cyclobutyl or cyclopentyl; provided R^a and R^b both represent hydrogen, or both represent methyl simultaneously, R³ represents (1-methylcyclopropyl)methyl, which possess the inhibitory action on 11b-HSD1.

EFFECT: preparing the compounds, which possess the inhibitory action on 11b-HSD1.

15 cl, 1 tbl, 32 ex