FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to 4-arylcumarine derivatives and a based drug which can be used for treating tumours of general formula
, where A means a group 
, where CnHm represents residual fatty acids of saturate and olefin series, n represents number 13, 15 or 17, m represents number 27, 31 or 33, while R1, R2, R3 represent hydrogen atoms and/or methoxygroup OCH3. The drug contains said 4-arylcumarine derivatives contained in liposomes containing phosphatidylcholine, phosphatidylinositol and lipid oligopolysaccharide.
EFFECT: there are prepared the new oncology compounds and the new drug showing lesser systemic toxicity and greater membrane affinity.
12 cl, 9 ex, 1 tbl, 3 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF 3-AMINOMETHYLQUINOLONE-2 AS INHIBITORS OF NO-SYNTHETASE AND METHOD FOR THEIR PREPARING, BIOLOGICALLY ACTIVE COMPOUNDS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2003 |
|
RU2267485C2 |
| METHOD FOR PREPARING OPTICALLY ACTIVE TETRALINE | 2001 |
|
RU2286994C2 |
| METHOD OF OBTAINING MORPHOLINYLANTHRACYCLINE DERIVATIVES | 2011 |
|
RU2563638C2 |
| FLUORINE-CONTAINING TEVINOL AND ORVINOL DERIVATIVES AND METHODS OF THEIR OBTAINING (VERSIONS) | 2012 |
|
RU2506265C1 |
| METHOD OF PRODUCING 4-ARYL-2-OXO-2H-CHROMENE-3-CARBONITRILES | 2015 |
|
RU2577524C1 |
| DERIVATIVES OF PHENYL-3-AMINOMETHYLQUINOLONE-2 AS INHIBITORS OF NO-SYNTHASE, METHOD FOR THEIR PREPARING, BIOLOGICALLY ACTIVE COMPOUNDS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2003 |
|
RU2284325C2 |
| ANTHRACYCLINE GLYCOSIDES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS SHOWING ANTITUMOR PROPERTIES, AND A METHOD OF THEIR SYNTHESIS | 1990 |
|
RU2043360C1 |
| SUBSTITUTED BENZ[A]ACRIDINES, PHARMACEUTICAL COMPOSITION, THERAPEUTIC METHOD OF INHIBITION OF CANCER CELL PROLIFERATION | 1997 |
|
RU2174116C2 |
| BENZOTHIAZOLE DERIVATIVE OR ITS PHARMACOLOGICALLY ACCEPTABLE SALT | 1992 |
|
RU2041216C1 |
| 1,2,3,6-TETRAHYDROPYRROLO [1,2-d][1,4]DIAZOCINES DERIVATIVES PREPARATION METHOD | 2008 |
|
RU2378279C1 |
