4-ARYLCUMARINE DERIVATIVES AND BASED ONCOLOGY DRUG Russian patent published in 2012 - IPC C07D311/18 A61K31/352 A61P35/00 

Abstract RU 2440998 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to 4-arylcumarine derivatives and a based drug which can be used for treating tumours of general formula

, where A means a group , where CnHm represents residual fatty acids of saturate and olefin series, n represents number 13, 15 or 17, m represents number 27, 31 or 33, while R1, R2, R3 represent hydrogen atoms and/or methoxygroup OCH3. The drug contains said 4-arylcumarine derivatives contained in liposomes containing phosphatidylcholine, phosphatidylinositol and lipid oligopolysaccharide.

EFFECT: there are prepared the new oncology compounds and the new drug showing lesser systemic toxicity and greater membrane affinity.

12 cl, 9 ex, 1 tbl, 3 dwg

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RU 2 440 998 C1

Authors

Fedorov Aleksej Jur'Evich

Sitnikov Nikolaj Sergeevich

Vodovozova Elena L'Vovna

Moiseeva Ekaterina Viktorovna

Boldyrev Ivan Aleksandrovich

Kuznetsova Natal'Ja Rostislavovna

Beletskaja Irina Petrovna

Sebast'Jan Komb

Dates

2012-01-27Published

2010-08-02Filed