METHOD FOR PREPARING OPTICALLY ACTIVE TETRALINE Russian patent published in 2006 - IPC C07H15/252 C07C69/14 

Abstract RU 2286994 C2

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for synthesis of optically active tetraline of the formula (I): . Synthesis is carried out from 5,8-dimethoxy-3,4-dihydronaphthalene by the following steps: (1) acylation in the presence of AlCl3 excess at temperature -35-25°C; (2) enantioselective dihydroxylation by Sharpless in the presence of the catalytic amount of osmium salt; (3) preparing 1-chloro-2-acetyl derivative; (3) dihydrochlorination and the following hydrolysis. Method provides the significant increasing the yield of the end substance.

EFFECT: improved method of synthesis.

5 cl, 6 ex

Similar patents RU2286994C2

Title Year Author Number
3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-c] PYRROLES AS GLUCOKINASE ACTIVATORS 2011
  • Sarabu Ramakantkh
RU2603191C2
METHOD OF PRODUCING (S)-(-)-6-BENZYLOXY-3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-2H-1-BENZOPYRAN-2-YLMETHANOL 2010
  • Shafikov Ruslan Vavisovich
  • Spivak Anna Jul'Evna
  • Odinokov Viktor Nikolaevich
RU2443695C1
METHOD OF PRODUCING 2-AMINO-5,8-DIMETHOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE FROM 4-CHLORO-2,5-DIMETHOXYPYRIMIDINE 2013
  • Blend Duglas K.
  • Rot Gari
  • Bott Krejg
  • Khemilton Kristofer T.
  • Nyuman Dzhozef
RU2635352C2
METHOD FOR PRODUCTION OF ANTHRACYCLONES 1990
  • Valter Kabri[Jt]
  • Ilaria Kandiani[Jt]
  • Silvia De Bernardinis[Jt]
  • Franko Frankolanchi[Jt]
RU2077526C1
(E)-2-(4-{ [3-(2,4-DIMETHOXYPHENYL)ACRYLAMIDO]METHYL} -1H-1,2,3-TRIAZOLE-1-YL)-2-ISOPROPYL-9-(4-METHYL PIPERAZINE-1-YL)-3,7-DIOXO-3,7-DIHYDRO-2H-FURO[3,2-g]CHROMEN, HAVING ANALGESIC ACTIVITY 2014
  • Shul'Ts Ehl'Vira Ehduardovna
  • Lipeeva Alla Viktorovna
  • Dolgikh Margarita Petrovna
  • Morozova Ekaterina Aleksandrovna
  • Tolstikova Tat'Jana Genrikhovna
RU2549574C1
METHOD FOR MAKING 2-AMINO-4-ARYL-6-HEXYL-7-HYDROXY-4H-CHROMEN-3-CARBONITRILES 2022
  • Khalatian Karina Vaganovna
  • Dotsenko Viktor Viktorovich
  • Russkikh Alena Andreevna
  • Varzieva Ekaterina Anatolevna
RU2802631C1
METHOD FOR PRODUCING 3,4-DIALKOXY-2,5-THIOPHENEDICARBOXIC ACID ESTERS 2021
  • Skalin Maksim Dmitrievich
  • Mantrov Sergej Nikolaevich
  • Nefedov Pavel Andreevich
RU2778232C1
METHOD FOR PREPARING 1-SUBSTITUTED 3,3-DIMETHYL-3,4- DIHYDROISOQUINOLINES 2001
  • Shkljaev Ju.V.
  • Glushkov V.A.
  • Nifontov Ju.V.
RU2213735C2
4-SUBSTITUTED ANTHRACYCLINONES AND ANTHRACYCLINE GLYCOSIDE 1991
  • Uolter Kabri[It]
  • Sil'Vija De Bernardinis[It]
  • Franko Frankalanchi[It]
  • Serdzho Penko[It]
RU2024483C1
METHOD OF PRODUCING 4-ARYL-SUBSTITUTED 7-HYDROXY-6'-PHENYL-5',6'-DIHYDRO-1'H-SPIRO[CHROMAN-2,4'-PYRIMIDINE]-2'(3'H)-ONES 2023
  • Karandeeva Alena Sergeevna
  • Uryadova Anastasiya Mikhajlovna
  • Makarova Elena Sergeevna
  • Filimonov Sergej Ivanovich
  • Kabanova Mariya Valerevna
  • Chirkova Zhanna Vyacheslavovna
  • Abramov Igor Gennadevich
RU2818006C1

RU 2 286 994 C2

Authors

Di Bun'O Kristina

D Arata Fabio

Ramachchotti Alessio

Krotti Paolo

Dates

2006-11-10Published

2001-11-15Filed