FIELD: biotechnologies.
SUBSTANCE: invention pertains to new compounds that have the properties of HCV virus replication inhibitor. In expression I: , A1 is C6aryl, substituted by -X1-R7; X1 is -S-; R7 is C6aryl, not necessarily substituted by one RA; Z1 is -N(RB)-; each of W1 and W2 is N; R1 is hydrogen; R3 and R4 together with carbon atoms, to which they are connected, form 6-member heterocyclic ring containing N as heteroatom, where 6-member heterocyclic ring is not necessary substituted by one RA; A2 represents C6aryl or 5-member heterocyclyl containing N as heteroatom; R2 represents -N(Rb)C(O)C(R5R6)N(R8)-T-Rd,
or -LK-B; R6 and R8 together with atoms, to which they are connected, form 5-member heterocyclic ring; the values of radicals RA, R5, T, RC, RD, RD' and RD", LK, B are given in the invention's expression. Invention also pertains to pharmaceutical composition containing the said compounds, method for inhibiting HCV virus replication, method for HCV infection curing and method for obtaining the said compounds.
EFFECT: improving compound application efficiency.
25 cl, 6 tbl, 18 ex
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Authors
Dates
2014-01-27—Published
2009-12-22—Filed