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2 505 540

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IPC

C07D471/04(2006-01-01)

A61K31/519(2006-01-01)

C07D487/04(2006-01-01)

A61P31/14(2006-01-01)

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Application

2011130833/04, 2009-12-22

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Start date

2009-12-22

(22)

Actual filing date

2009-12-22

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Published

2014-01-27

(72)

Inventor

Degoj Dehvid A.Donner Pamela L.Kati Uorren M.Khatchins Charl'Z V.Matulenko Mark A.Dzhinkerson Tammi K.Keddi Rajan Dzh.

(73)

Holder

Ehbbvi Ink.

ANTIVIRAL COMPOUNDS Russian patent published in 2014 - IPC C07D471/04 A61K31/519 C07D487/04 A61P31/14 

Abstract RU 2505540 C2

FIELD: biotechnologies.

SUBSTANCE: invention pertains to new compounds that have the properties of HCV virus replication inhibitor. In expression I: , A1 is C6aryl, substituted by -X1-R7; X1 is -S-; R7 is C6aryl, not necessarily substituted by one RA; Z1 is -N(RB)-; each of W1 and W2 is N; R1 is hydrogen; R3 and R4 together with carbon atoms, to which they are connected, form 6-member heterocyclic ring containing N as heteroatom, where 6-member heterocyclic ring is not necessary substituted by one RA; A2 represents C6aryl or 5-member heterocyclyl containing N as heteroatom; R2 represents -N(Rb)C(O)C(R5R6)N(R8)-T-Rd, or -LK-B; R6 and R8 together with atoms, to which they are connected, form 5-member heterocyclic ring; the values of radicals RA, R5, T, RC, RD, RD' and RD", LK, B are given in the invention's expression. Invention also pertains to pharmaceutical composition containing the said compounds, method for inhibiting HCV virus replication, method for HCV infection curing and method for obtaining the said compounds.

EFFECT: improving compound application efficiency.

25 cl, 6 tbl, 18 ex

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RU 2 505 540 C2

Authors

Degoj Dehvid A.

Donner Pamela L.

Kati Uorren M.

Khatchins Charl'Z V.

Matulenko Mark A.

Dzhinkerson Tammi K.

Keddi Rajan Dzh.

Dates

2014-01-27—Published

2009-12-22—Filed

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