FIELD: organic chemistry, medicine, virology.
SUBSTANCE: invention relates to technology of organic compounds, namely, to 5'-aminocarbonylphosphonates d4T that are inhibitors of the human immunodeficiency virus reproduction. Invention describes 5'-aminocarbonylphosphonates d4T of the general formula: 
wherein R' means hydrogen atom (H), alkyl, aryl; R'' means hydrogen atom (H), alkyl, aryl; R', R'' mean cyclic alkyl; R means alkyl. These compounds are inhibitors of the human immunodeficiency virus reproduction. Invention provides preparing new compounds eliciting valuable biological properties.
EFFECT: valuable medicinal properties of compounds.
2 dwg, 1 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE-5'-[(ETHOXY-CARBONYL)(ETHYL)PHOSPHONATE] AS INHIBITOR OF REPRODUCTION OF HUMAN IMMUNODEFICIENCY VIRUS | 2000 |
|
RU2188203C2 |
| NUCLEOSIDE ANALOG PHOSPHORAMIDATES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPRODUCTION | 2003 |
|
RU2243972C1 |
| DERIVATIVES OF 3'-AZIDO-3'-DEOXYTHYMIDINE 5'-H-PHOSPHONATE AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF | 2001 |
|
RU2187509C1 |
| 5'-PHOSPHORUS-CONTAINING DERIVATIVES OF 2',3'-DIDEOXY-3'-THIACYTIDINE - NEW ANTIVIRAL AGENTS | 2007 |
|
RU2373218C2 |
| MODIFIED 5'-PHOSPHONATES OF 3'-AZIDO-3'-DEOXYTHYMIDINE AS ACTIVE COMPONENTS FOR POTENTIAL ANTIVIRAL PREPARATIONS | 2004 |
|
RU2322450C2 |
| 5'-AMINOCARBONYLPHOPHONATE 3'-AZIDO-3'-DEOXYTHYMIDINE SALTS BEING SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS HIV-1 | 2010 |
|
RU2441016C1 |
| NOVEL DEPOT-FORMS OF ZIDOVUDINE AND LAMIVUDINE BASED ON PHOSPHONIC ACID DERIVATIVES | 2009 |
|
RU2430104C1 |
| MODIFIED NUCLEOSIDE-5'-TRIPHOSPHATES AS ANTIVIRAL AGENTS | 1996 |
|
RU2183213C2 |
| URETHANE AZT DERIVATIVES - POTENTIAL ANTIVIRAL AGENTS | 2009 |
|
RU2430103C1 |
| 3'-AZIDO-3'-DEOXYTHYMIDINE 5'-CHOLINE PHOSPHATE AS ANTIVIRAL AGENT | 2002 |
|
RU2293739C2 |
