ARYL COMPOUNDS AS PPAR LIGANDS AND THEIR APPLICATION Russian patent published in 2012 - IPC C07C323/20 C07D213/32 C07D231/08 C07D413/04 A61K31/415 A61K31/4155 A61K31/435 A61P3/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound of formula I

,

where A represents S or Se; B represents H or ; R₁ represents aryl selected from the following structures:

R₂ represents H or ; R₃ represents H or C1-C8 alkyl; R₄ and R₅ independently represent H or C1-C8 alkyl; R₆ represents H, C1-C8 alkyl, C2-C7 alkenyl, alkaline metal or alkaline earth metal; R₁₁ and R₁₂ independently represent H, C1-C8 alkyl or halogen; R₂₁ represent H, halogen or C1-C7 alkyl; m and n independently represent integers having values 1-4; p represents an integer having a value of 1-5; q represents an integer having a value of 1-4; r represents an integer having a value of 1-3; s represents an integer having a value of 1-5; as an activator of peroxisome proliferator-activated receptor (PPAR) and its hydrate, solvate, stereoisomer and pharmaceutically acceptable salt, and to a pharmaceutical composition.

EFFECT: preparing an agent for muscle strengthening, an agent for memory improvement, a therapeutic agent for dementia and Parkinson's disease.

15 cl, 8 tbl, 348 ex