SELENAZOLE DERIVATIVE, HAVING LIGAND ACTIVATING PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR), METHOD FOR PRODUCTION THEREOF AND USE OF CHEMICAL COMPOUNDS Russian patent published in 2014 - IPC C07D293/06 A61K31/95 A61P3/04 A61P3/06 A61P9/10 

Abstract RU 2510394 C1

FIELD: chemistry.

SUBSTANCE: compound has formula I: |Chemical formula 1| where A is O, NR, S, S(=O), S(=O)2 or Sc; B is hydrogen or ; R1 is hydrogen, C1-C8 alkyl or halogen; R2 is hydrogen, C1-C8 alkyl, or ; Xa and Xb is independently CR or N; R is hydrogen or C1-C8 alkyl; R3 is hydrogen, C1-C8 alkyl; R4 and R5 are independently hydrogen, halogen or C1-C8 alkyl; R6, is hydrogen. C1-C8 alkyl, or a pharmaceutically acceptable organic salt; R21, R22 and R23 are independently hydrogen, halogen, NO2, C1-C7 alkyl, unsubstituted or substituted with halogen, C3-C12 heteroaryl, containing one or more heteroatoms selected from N, O and S; m equals an integer from 1 to 4; p equals an integer from 1 to 5; s equals an integer from 1 to 5; u equals an integer from 1 to 3; w equals an integer from 1 to 4; and alkyl in R1, R3, R4, R5 and R6 can further be substituted with one or more halogens, C3-C7 cycloalkyl or C1-C5 alkylamine. Also disclosed are methods of producing selenazole derivatives, a pharmaceutical composition, a functional feed additive composition, a functional beverage, a food additive, animal feed, a functional cosmetic composition, a peroxisome proliferator-activated receptor (PPAR) activator composition.

EFFECT: invention enables to obtain a selenazole derivative which activates a peroxisome proliferator-activated receptor.

15 cl, 1 dwg, 6 tbl, 298 ex

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RU 2 510 394 C1

Authors

Kang Kheondzoong

Chin Dzungvook

Li Dzaekhvan

Dates

2014-03-27Published

2010-02-25Filed