THIAZOLE DERIVATIVES AS PPAR-DELTA LIGANDS AND OBTAINMENT METHOD Russian patent published in 2010 - IPC C07D277/26 C07D417/12 A61K31/426 A61K31/4427 A61P3/04 A61P3/10 A61P3/06 A61P9/10 

FIELD: chemistry.

SUBSTANCE: claimed compounds show effect on receptor activated by peroxysome proliferate δ (PPARδ). In formula I: [Formula I] , [Formula VII] , [Formula VI] , A is R₁ is C_1-4alkyl group; R₃ groups are different and denote halogen atom or C_1-4alkyl group substituted or unsubstituted by halogen; R₄ is R₅ is hydrogen atom or hydroxyl group; the other radicals are as defined in the invention claim. Also invention refers to methods of compound I obtainment, to intermediary compounds VI, VII and methods of their obtainment, to medicines of diabetes, obesity, atherosclerosis, hyperlipidemia treatment and prevention, containing thiazole derivative of the formula I as active component.

EFFECT: enhanced activity of derivatives.

21 cl, 10 tbl, 102 ex