INDAZOLE ACRYLIC ACID AMIDE DERIVATIVE Russian patent published in 2012 - IPC C07D231/56 C07D401/12 C07D403/12 C07D405/12 C07D413/12 C07D417/12 C07D471/04 A61K31/416 A61K31/427 A61K31/437 A61K31/454 A61K31/496 A61K31/5377 A61K31/551 A61K31/553 A61P9/06 A61P43/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula

and ,

where the ring X represents benzole or pyridine; R¹ represents substituted alkyl; R² represents optionally substituted aryl or optionally substituted 4-7-member monocyclic heterocyclic group or optionally substituted condensed group of heterocyclic group with the benzole ring where the substitutes of optionally substituted aryl, optionally substituted 4-7-member monocyclic heterocyclic group and optionally substituted condensed group of heterocyclic group with the benzole ring are selected from a group consisting of; (1) alkyl optionally substituted by a group selected from halogen and alkoxycarbonyl, (2) alkoxy optionally substituted by halogen, (3) halogen, (4) 4-7-member monocyclic heterocyclic group or (5) amino, optionally mono- or disubstituted alkyl, and (6) hydroxyl, R³ represents hydrogen or alkyl: R⁴ represents hydrogen, halogen or alkyl; R⁵ represents hydrogen or alkyl; R⁶ and R⁷ are identical or different, and each represents hydrogen or halogen; or pharmaceutically acceptable salt. Also, the invention refers to a I_Kur blocker containing the compounds described above as an active ingredient, and also to a preventive and therapeutic agent for cardiac arrhythmia and atrial fibrillation.

EFFECT: there are produced and described new compounds applicable as a I_Kur blocker effective for preventing or treating cardiac arrhythmia, such as atrial fibrillation.

12 cl, 13 ex