FIELD: chemistry.
SUBSTANCE: invention relates to a compound having formula [I], in which RA represents (a) group having formula (A-1), where cycle A1 is (1) C3-8 cycloalkyl group, which can be substituted with C1-6 alkyl group, (2) C3-8 cycloalkenyl group which can be substituted with C1-6 alkyl group, (3) a phenyl group which can be substituted with 1–3 groups independently selected from a group consisting of a halogen atom, C1-6 alkyl group, C1-6 haloalkyl group, C1-6 alkoxyalkyl group, C1-6 alkoxy groups and C1-6 alkylenedioxy groups which can be substituted with 1 to 2 halogen atoms, (4) a naphthyl group which can be partially hydrogenated and can be substituted with C1-6 alkyl group, (5) a heteroaryl group which can be partially hydrogenated and can be substituted with 1–2 groups independently selected from a group consisting of a cyano group and C1-6 alkyl group, heteroaryl fragment is pyridyl, indazolyl, thienyl, isoquinolyl, benzopyranyl, benzofuranyl, indolyl or benzothiazolyl, RB represents a group having formula (B-4) shown below, in which Xa is CR3a or N, (i) when Xa is CR3a, Xb is CHR3b, Xc is O or NR4c, Xb is O, Xc is NR4c, or Xb is NR4b, Xc is O, NR4c or CHR3c, (ii) when Xa is N, Xb is CHR3b or C(=O), Xc is NR4c, or Xb is NR4b, Xc is CHR3c; R3a represents a hydrogen atom, other radical values are given in the claim. Invention also relates to individual compounds and to a method of treating various diseases and/or pathological conditions caused by high aldosterone and/or excessive production of aldosterone.
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EFFECT: technical result is obtaining novel compounds of formula [I], having aldosterone synthetase inhibiting action.
13 cl, 44 tbl, 373 ex
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