FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology, particularly to a method for preparing a combined bivalent, tissue-culture, inactivated, concentrated, purified vaccine for preventing hemorrhagic fever and renal syndrome (HFRS). Substance of the invention involves reproduction of strains "ПУУ-ТКД/VERO" and "ДОВ-ЕАТ/VERO" of PUUMALA and DOBRABA viruses in a multilayer passaged culture of VERO-line grivet monkey's kidneys involving microfiltration of a virus-containing culture fluid to remove cell debris, virus inactivation by formalin, concentration by ultrafiltration and chromatography purification of the inactivated concentrated from ballast proteins, aluminium hydroxide sorption.
EFFECT: provided creation of the vaccine to be applied in European Russia and other European countries.
8 cl, 3 ex
| Title | Year | Author | Number |
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|
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|
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| METHOD OF PRODUCTION OF RECOMBINANT ANTIGEN G2 OF HANTAVIRUS DOBRAVA IN CELLS OF E coli | 2011 |
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| METHOD OF PREPARING INACTIVATED VACCINE AGAINST CLASSIC PLAGUE IN PIGS | 1993 |
|
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| METHOD OF PREPARING VACCINE AGAINST HEPATITIS A | 1989 |
|
SU1672635A1 |
