FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to heterocyclic compounds of formula ,
wherein X2 represents residue C-Z-R2 or C-R3, wherein Z represents NH or S; R1 is selected from structures , and R2 and R3 have the values specified in cl.1 of the patent claim, or to their pharmaceutically acceptable salts. The invention also refers to a pharmaceutical composition, a series of specific compounds, application of the declared compounds and to an intermediate compound for preparing the compounds of formula (I).
EFFECT: compounds under the invention have affinity to muscarine receptors and can be used in treating, relieving and preventing diseases and conditions mediated by muscarine receptors.
13 cl, 3 tbl
Title | Year | Author | Number |
---|---|---|---|
PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE | 2011 |
|
RU2617405C2 |
N1/N2-LACTAM ACETYL-CoA-CARBOXYLASE INHIBITORS | 2011 |
|
RU2540337C2 |
PYRAZOLO [3,4-C] PYRIDINES AND METHODS OF APPLICATION THEREOF | 2012 |
|
RU2638116C2 |
PYRAZOLOPYRIMIDINE-BASED JAK INHIBITING COMPOUNDS AND METHODS | 2010 |
|
RU2567238C2 |
INHIBITING JAK COMPOUNDS BASED ON PYRAZOLOPYRIMIDINE AND METHODS | 2010 |
|
RU2675857C2 |
PYRIDYL DIMETHYLSULPHONIC DERIVATIVE | 2006 |
|
RU2404968C2 |
BICYCLIC TETRAHYDROPYRAZOLEPYRIDINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION, METHOD OF PHOSPHODIESTERASE INHIBITION, METHOD OF PATIENT TREATMENT | 1994 |
|
RU2131876C1 |
CYCLOHEXANE DERIVATIVE AND ITS PHARMACEUTICAL USE | 2009 |
|
RU2478621C2 |
TRKA KINASE INHIBITORS, COMPOSITIONS BASED THEREON AND METHODS | 2015 |
|
RU2672583C2 |
NEW DERIVATIVES OF IMIDAZO [4,5-C] QUINOLINES AND IMIDAZO [4,5-C] [1,5] NAPHTHYRIDINES AS LRRK2 INHIBITORS | 2016 |
|
RU2722149C1 |
Authors
Dates
2012-03-27—Published
2008-04-23—Filed