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Application

2002124490/13, 2002-09-10

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Start date

2002-09-10

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Actual filing date

2002-09-10

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Published

2004-09-20

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Inventor

Andrjushina V.A.Arinbasarova A.Ju.Vojshvillo N.E.Savinova T.S.Sazonova A.S.Stytsenko T.S.

(73)

Holder

Zakrytoe Aktsionernoe Obshchestvo Laboratorii"

METHOD FOR PREPARING METANDROSTENOLONE Russian patent published in 2004 - IPC

Abstract RU 2236464 C2

FIELD: biotechnology, microbiology, steroids.

SUBSTANCE: invention relates, in particular, to preparing steroids. Method for preparing metandrostenolone (17β-hydroxy-17-methylandrosta-1,4-diene-3-one) involves microbiological transformation of 17α-methyltestosterone by microorganism strains eliciting activity of 3-ketosteroid-1,2-dehydrogenase. Process is carried out in the presence polymeric material - polyvinylpyrrolidone with the following isolation of the end product. Arthrobacter globiformis, Pimelobacter simplex or Rhodococcus erythropolis are used as microorganisms. Method allows elevating loading on substrate, to simplify process, to reduce its duration and to enhance the yield. Method is safe ecologically.

EFFECT: improved preparing method.

2 cl, 3 ex

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RU 2 236 464 C2

Authors

Andrjushina V.A.

Arinbasarova A.Ju.

Vojshvillo N.E.

Savinova T.S.

Sazonova A.S.

Stytsenko T.S.

Dates

2004-09-20—Published

2002-09-10—Filed