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IPC

C07J5/00(2006-01-01)

C12P33/02(2006-01-01)

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Application

2011146244/04, 2011-11-16

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Start date

2011-11-16

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Actual filing date

2011-11-16

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Published

2013-04-27

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Inventor

Fokina Viktorija Valer'EvnaSukhodol'Skaja Galina ViktorovnaShutov Andrej Anatol'EvichNikolaeva Vera MaksimovnaDonova Marina ViktorovnaSavinova Tat'Jana StepanovnaLukashev Nikolaj VadimovichSurovtsev Viktor Vasil'Evich

(73)

Holder

Rossijskaja Federatsija, Ot Imeni Kotoroj Vystupaet Ministerstvo Promyshlennosti I Torgovli Rossijskoj Federatsii

MICROBIOLOGICAL METHOD OF PRODUCING 21-ACETOXYPREGNA-1,4,9( 11 ),16-TETRAENE-3,20-DIONE FROM 21-ACETOXYPREGNA-4,9( 11 )16-TRIENE-3,20-DIONE Russian patent published in 2013 - IPC C07J5/00 C12P33/02

Abstract RU 2480475 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a highly efficient microbiological method of producing 21-acetoxypregna-1,4,9(11),16-tetraene-3,20-dione from 21-acetoxypregna-4,9(11),16-triene-3,20-dione. The 1,2-dehydrogenation of 21-acetoxypregna-4,9(11),16-triene-3,20-dione is carried out using Nocardioides simplex BKM Ac-2033D cells at temperature of 25°C in the medium of a buffer solution with pH 5.0-5.5, which contains methyl-β-cyclodextrin, a water-miscible polar solvent and an exogenous electron acceptor.

EFFECT: use of a growing culture or deposited cells enables to conduct transformation with a high substrate load with complete selective conversion of the substrate to a 1,2-dehydrogenated product and high rate of the process.

7 cl, 7 ex, 2 tbl

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RU 2 480 475 C1

Authors

Fokina Viktorija Valer'Evna

Sukhodol'Skaja Galina Viktorovna

Shutov Andrej Anatol'Evich

Nikolaeva Vera Maksimovna

Donova Marina Viktorovna

Savinova Tat'Jana Stepanovna

Lukashev Nikolaj Vadimovich

Surovtsev Viktor Vasil'Evich

Dates

2013-04-27—Published

2011-11-16—Filed