AZAINDOLIZINES AND METHODS FOR PREPARING THEM Russian patent published in 2013 - IPC C07D487/04 A61K31/437 A61K31/519 A61P35/00

Abstract RU 2483069 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel azoindolizines or pharmaceutically acceptable salts thereof having Mek-kinase inhibitory activity in formula : Z^A means CR^A; R^A means H or halogen; each of R¹, R² and R³ means H; W means: , each R⁴ and R⁵ means H; X¹ represents -OR⁷; each R⁷ means C₂-C₁₂-hydroxyalkyl, 2,3-dihydroxypropyl, C₂-C₃-alkenoxyC₁-C₆-alkoxy, (2,2-dimethyl-[1,3]dioxalan-4-yl)-methyl or piperidinyl; X⁴ means: R⁶ means halogen or -SR¹⁶; R⁶ means halogen; p is equal to 1; R¹⁶ means C₁-C₁₂-alkyl.

EFFECT: invention relates to a pharmaceutical compositions containing these compounds, to a method of inhibiting the abnormal cell growth and the use of the compounds for preparing a drug preparation for inhibiting the abnormal cell growth.

9 cl, 10 ex

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RU 2 483 069 C2

Authors

Prajs Stefen

Khild Robert

Kh'Juitt Piter

Dates

2013-05-27—Published

2008-12-19—Filed