METHOD OF PRODUCING 16(S)-DIHYDROSTEVIOL Russian patent published in 2012 - IPC C07C61/08 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to an improved method of producing 16(S)-dihydrosteviol of formula (I), which can be used in synthesis of novel ent-kaurane diterpenoid derivatives. (I). The method involves mixing glucoside (stevioside) of a Stevia rebaudiana plant or a mixture of glucosides of said plant (sweetener) with 100-fold excess hydroxylamine in dimethyl formamide, adding 70-fold excess ethyl acetate at room temperature and then heating the reaction mixture to 100°C for 3 hours, concentrating said reaction mixture, dissolving the residue in water acidified to pH 1-3, boiling the aqueous solution for 2 hours, extracting the product with diethyl ether, drying, distilling the solvent and recystallising the end product from ethyl acetate.

EFFECT: method ensures high output and does not require use of a catalyst.

1 cl, 2 ex