FLUORINATED CATHARANTINE DERIVATIVES, THEIR OBTAINING AND APPLICATION AS PRECURSORS OF DIMERIC VINCA ALKALOIDS Russian patent published in 2012 - IPC C07D209/14 C07D211/26 C07D211/70 C07D223/12 C07D471/22 C07D487/22 

Abstract RU 2448957 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to fluorinated catharantine derivatives of general formula I in which broken line represents possibility of double bond presence, when substitution X is absent, or simple bond, when X stands for substitution with another group: H, R1, R2 and R3 independent on each other represent a fluorine atom or methylated group, and n=2.

EFFECT: invention also relates to method of obtaining said derivative and to its application as intermediate compound for synthesis of fluorated dimeric Vinca alkaloids, in particular vinflunine, which in its turn is used as anti-cancer agent.

22 cl

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RU 2 448 957 C2

Authors

Muasan L'Onel'

Komess Sebast'En

Dzhovanelli Ehmerson

Russo Bernar

Dori Ehrik

Ehl'E Pol'

Dates

2012-04-27Published

2007-09-20Filed