FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to fluorinated catharantine derivatives of general formula I in which broken line represents possibility of double bond presence, when substitution X is absent, or simple bond, when X stands for substitution with another group: H, R1, R2 and R3 independent on each other represent a fluorine atom or methylated group, and n=2.
EFFECT: invention also relates to method of obtaining said derivative and to its application as intermediate compound for synthesis of fluorated dimeric Vinca alkaloids, in particular vinflunine, which in its turn is used as anti-cancer agent.
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Authors
Dates
2012-04-27—Published
2007-09-20—Filed